GILLES GOUSPILLOU, PhD
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SELECTED PUBLICATIONS

2026

  • Usmani SE, Leduc-Gaudet JP*, Chau S, Bellissimo CA, Vohra S, Desjardins K, Pollock-Tahiri E, Shi I, Chun F, Capobianco A, Delisle P, Dupebe W, Cefis M, Marcangeli V, Ghebreselassie M, Liang YC, Seki Y, Mayaki D, Hussain S, Goligher E, Kapoor M, Locke M, Gouspillou G*, Woo M*. BCL6 regulates skeletal muscle mass and mitochondrial bioenergetics. Mol Metab. 2026 Apr 13;108:102367. doi: 10.1016/j.molmet.2026.102367. Epub ahead of print. PMID: 41985672. *:co-senior and co-corresponding authors | Pubmed

  • Reynaud O, Ayoub MB, Leduc-Gaudet JP, Cefis M, Lussier MP, Hussain SN, Gouspillou G. Parkin overexpression attenuates muscle atrophy and improves mitochondrial bioenergetics but not histological features of Duchenne muscular dystrophy in mice. Sci Rep. 2026 Jan 17;16(1):4139. doi: 10.1038/s41598-025-34223-9. PMID: 41547930; PMCID: PMC12858866. | Pubmed

    • 2025

  • Chaney R, Marcangeli V, Desjardins K, Taherkhani S, Gouspillou G. Canonical and non-canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology. J Physiol. 2025 Nov 22. | Pubmed

  • Marcangeli, V., M. Cefis, R. Hammad, et al. (2025). Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans. Aging Cell e70191. | Aging Cell

  • Cefis, M., Marcangeli, V., Hammad, R., Granet, J., Leduc-Gaudet, J.-P., Gaudreau, P., Trumpff, C., Huang, Q., Picard, M., Aubertin-Leheudre, M., et al. (2024). Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Cell Reports Medicine, Volume 0, Issue 0, 101968. | Cell Reports Medicine

    • 2024

  • Dulac M, Hajj-Boutros G, Sonjak V, Faust A, Hussain SNA, Chevalier S, Dionne IJ, Morais JA*, Gouspillou G. A multimodal exercise countermeasure prevents the negative impact of head-down tilt bed rest on muscle volume and mitochondrial health in older adults. J Physiol. 2024 Jun 15. doi: 10.1113/JP285897. Epub ahead of print. PMID: 38878232. | Pubmed

  • Franco-Romero A, Leduc-Gaudet JP, Hussain SN, Gouspillou G, Sandri M. PHAF1/MYTHO is a novel autophagy regulator that controls muscle integrity. Autophagy. 2024 Apr;20(4):965-967. doi: 10.1080/15548627.2023.2224206. Epub 2023 Jun 12. PMID: 37309183; PMCID: PMC11062385. | Pubmed

  • Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, Gouspillou G. MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiol (Oxf). 2024 May;240(5):e14119. doi: 10.1111/apha.14119. Epub 2024 Feb 23. PMID: 38400630. | Pubmed

    • 2023

  • Leduc-Gaudet JP, Franco-Romero A, Cefis M, Moamer A, Broering FE, Milan G, Sartori R, Chaffer TJ, Dulac M, Marcangeli V, Mayaki D, Huck L, Shams A, Morais JA, Duchesne E, Lochmuller H, Sandri M, Hussain SNA, Gouspillou G, MYTHO is a novel regulator of skeletal muscle autophagy and integrity, Nature Communications 2023, 14 - 1199. | Pubmed

  • Leduc-Gaudet JP, Miguez K, Cefis M, Faitg J, Moamer A, Chaffer TJ, Reynaud O, Broering FE, Shams A, Mayaki D, Huck L, Sandri M, Gouspillou G, Hussain SNA. Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival. iScience. 2023 Jul 25;26(8):107475. doi: 10.1016/j.isci.2023.107475. PMID: 37588163; PMCID: PMC10425945. | Pubmed

  • Reynaud O, Wang J, Ayoub MB, Leduc-Gaudet JP, Mayaki D, Dulac M, Hussain SNA, Bergeron R, Gouspillou G., The impact of high-fat feeding and parkin overexpression on skeletal muscle mass, mitochondrial respiration, and H2O2 emission, Am J Physiol Cell Physiol . 2023 Feb 1;324(2):C366-C376. doi: 10.1152/ajpcell.00388.2022. | Pubmed

    • 2022

  • Leduc-Gaudet JP, Hussain SN, Gouspillou G, Parkin: a potential target to promote healthy ageing, J Physiol. 2022 Aug;600(15):3405-3421. doi: 10.1113/JP282567. | Pubmed

  • Marcangeli V, Youssef L, Dulac M, Carvalho LP, Hajj-Boutros G, Reynaud O, Guegan B, Buckinx F, Gaudreau P, Morais JA, Mauriège P, Noirez P, Aubertin-Leheudre M, Gouspillou G., Impact of high-intensity interval training with or without l-citrulline on physical performance, skeletal muscle, and adipose tissue in obese older adults, J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1526-1540. doi: 10.1002/jcsm.12955. | Pubmed

  • Junker A, Wang J, Gouspillou G, Ehinger JK, Elmér E, Sjövall F, Fisher-Wellman KH, Neufer PD, Molina AJA, Ferrucci L, Picard M., Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis, FASEB J. 2022 Feb;36(2):e22146. doi: 10.1096/fj.202101628R. | Pubmed

    • 2021

  • Leduc-Gaudet JP, Hussain SNA, Barreiro E, Gouspillou G., Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging. Int. J. Mol. Sci. 2021, 22(15), 8179; https://doi.org/10.3390/ijms22158179 | Pubmed

  • Dulac M, Leduc-Gaudet JP, Cefis M, Ayoub MB, Reynaud O, Anwar S, Moamer A, Nerry Ferreira MF, Hussain SN, Gouspillou G., Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice. The Journal of Physiology, 2020, 2021 Jul 6. doi: 10.1113/JP281752. Online ahead of print. | Pubmed

  • Hussain SNA, Sandri M, Gouspillou G., Editorial: Autophagy and Mitophagy in Skeletal Muscle Health and Disease.Front Physiol. 2021 Jun 9;12:703458. doi: 10.3389/fphys.2021.703458. | Pubmed

    • 2020

  • Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G., Drp1 Knockdown Induces Severe Muscle Atrophy and Remodelling, Mitochondrial Dysfunction, Autophagy Impairment and Denervation. The Journal of Physiology, 2020, 2020 Jun 15. doi: 10.1113/JP279802. Online ahead of print. | Pubmed

  • Leduc-Gaudet JP, Mayaki D, Reynaud O, Broering FE, Chaffer TJ, Hussain SNA, Gouspillou G., Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting, Cells, 2020, 9(6):E1454. | Pubmed

    • 2019

  • Faitg J, Leduc-Gaudet JP, Reynaud O, Ferland G, Gaudreau P, Gouspillou G, Effects of Aging and Caloric Restriction on Fiber Type Composition, Mitochondrial Morphology and Dynamics in Rat Oxidative and Glycolytic Muscles. Frontiers in Physiology - Striated Muscle Physiology, 2019, 10:420. | Pubmed

  • Leduc-Gaudet JP, Reynaud O, Hussain SN, Gouspillou G., Parkin overexpression protects from aging-related loss of muscle mass and strength, The Journal of Physiology, 2019, 597(7):1975-1991. | Pubmed

    • 2018

  • Gouspillou G, Godin R, Piquereau J, Picard M, Mofarrahi M, Mathew J, Purves-Smith FM, Sgarioto N, Hepple RT, Burelle Y, Protective role of Parkin in skeletal muscle contractile and mitochondrial function, The Journal of Physiology, 2018, 596(13):2565-2579. | Pubmed

  • Leduc-Gaudet JP, Reynaud O, Chabot F, Mercier J, Andrich DE, St-Pierre DH, Gouspillou G, The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats. Physiol Rep. 2018 Feb;6(4). doi: 10.14814/phy2.13548. | Pubmed

    • 2017

  • St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovilé Í, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M & Gouspillou G,The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men. The Journal of Cachexia, Sarcopenia and Muscle, 2017 Apr;8(2):213-228. | Pubmed

    • 2016

  • Gouspillou G and Hepple RT, Mitochondria in skeletal muscle health, aging and diseases, Frontiers in Physiology, Striated muscle Physiology 2016 Oct 6;7:446. eCollection 2016. | Pubmed

  • Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan N, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RT, Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J. Physiol. 2016, Sep 13. doi: 10.1113/JP272487 | Pubmed

    • 2015

  • Diolez P., Bourdel-Marchasson I., Calmettes G., Padois P., Detaille D., Rouland R. and Gouspillou G, Hypothesis on skeletal muscle aging : mitochondrial adenine nucleotide translocator decreases reactive oxygen species production while preserving coupling efficiency, Frontiers in Physiology, Striated muscle Physiology 2015, 16;6:369. doi: 10.3389/fphys.2015.00369.
    | Pubmed

  • Leduc-Gaudet J.P., Auger M.J., St-Jean Pelletier F. and Gouspillou G, Towards a better understanding of the role played by mitochondrial dynamics and morphology in skeletal muscle atrophy, J. Physiol. 2015, 593(14): 2993-2994. PubMed Link
    | Pubmed

  • Leduc-Gaudet J.P., Picard M, St-Jean Pelletier F., Sgarioto N, Auger M.J., Vallée J., Robitaille R., St-Pierre D.H. and Gouspillou G, Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice, Oncotarget 2015, Advanced Publicaiton (ahead of print).
    | Pubmed

  • Gouspillou G, Scheede-Bergdahl C, Spendiff S, Vuda M, Meehan B, Mlynarski H, Archer-Lahlou E, Sgarioto N, Purves-Smith FM, Konokhova Y, Rak J, Chevalier S, Taivassalo T, Hepple RT, Jagoe RT., Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle., Sci Rep. 2015, 5:8717.
    | Pubmed

    • 2014

  • Gouspillou G, Sgarioto N, Norris B, Barbat-Artigas S, Aubertin-Leheudre M, Morais JA, Burelle Y, Taivassalo T, Hepple RT., The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans, PLoS One, 2014 Aug 14;9(8): e103044.
    | Pubmed

  • Gouspillou G, Sgarioto N, Kapchinsky S, Purves-Smith F, Norris B, Pion CH, Barbat-Artigas S, Lemieux F, Taivassalo T, Morais JA, Aubertin-Leheudre M, Hepple RT, Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans, FASEB J. 2014 Apr;28(4):1621-33.
    | Pubmed

  • Gouspillou G, Bourdel-Marchasson I, Rouland R, Calmettes G, Biran M, Deschodt-Arsac V, Miraux S, Thiaudiere E, Pasdois P, Detaille D, Franconi JM, Babot M, Trézéguet V, Arsac L, Diolez P, Mitochondrial energetics is impaired in vivo in aged skeletal muscle, Aging Cell. 2014 Feb;13(1):39-48.
    | Pubmed

    • 2013

  • Gouspillou G, Picard M, Godin R, Burelle Y, Hepple RT, Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses, Longev Healthspan. 2013 Aug 1;2(1):13.
    | Pubmed

  • Mofarrahi M, Guo Y, Haspel JA, Choi AM, Davis EC, Gouspillou G, Hepple RT, Godin R, Burelle Y, Hussain SN, Autophagic flux and oxidative capacity of skeletal muscles during acute starvation, Autophagy. 2013 Oct 1;9(10):1604-20.
    | Pubmed

  • Gouspillou G, Hepple RT, Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion,Exp Gerontol. 2013 Oct;48(10):1075-84.
    | Pubmed

    • 2011

  • Picard M, Taivassalo T, Gouspillou G, Hepple RT, Mitochondria: isolation, structure and function,J Physiol. 2011 Sep 15;589(Pt 18):4413-21 | Pubmed

  • Gouspillou G, Rouland R, Calmettes G, Deschodt-Arsac V, Franconi JM, Bourdel-Marchasson I, Diolez P, Accurate determination of the oxidative phosphorylation affinity for ADP in isolated mitochondria, PLoS One. 2011;6(6):e20709.
    | Pubmed

    • 2010

  • Gouspillou G, Bourdel-Marchasson I, Rouland R, Calmettes G, Franconi JM, Deschodt-Arsac V, Diolez P, Alteration of mitochondrial oxidative phosphorylation in aged skeletal muscle involves modification of adenine nucleotide translocator, Biochim Biophys Acta. 2010 Feb;1797(2):143-51.
    | Pubmed

  • Full list of publications : Pubmed

    • Faculté des Sciences, UQÀM